Advances in cell line engineering and microfluidic technologies provide significant opportunities to reduce timelines in cell line development (CLD). As with any change, optimizing the CLD processes can introduce new challenges and uncertainties. Some of the key challenges include: 1) selection bias in the cell line; 2) unpredictable gene expression; 3) issues with automated cloning techniques; 4) varying cell growth rates.
Download our eBook to learn how you can conquer these four challenges by:
- Ensuring robust validation of clones to offset selection bias.
- Using targeted integration to reducing clonal variation during cell line engineering.
- Leveraging picodroplet technology for high-efficiency, high-throughput, and high viability.
- Designing statistical experiment to develop the optimal medium formulation to support cell growth.